Synthesis of Spatial Exposomics and Analogue Gravity in Gastrointestinal Oncology: An Updated Model for Pesticide-Induced Carcinogenesis
This paper synthesizes high-resolution spatial exposomics with analogue gravity biophysics to elucidate the etiology of pesticide-induced gastrointestinal malignancies. Spatial risk mapping demonstrates that chronic exposure to sub-lethal pesticide mixtures disproportionately targets endoderm-derived tissues. Rather than mutating DNA, these xenobiotics act as profound non-genotoxic stressors, triggering Polycomb Repressive Complex 2-mediated epigenetic silencing that destabilizes core regulatory circuitries and lineage-specific master transcription factors.