The Entropic Arrow of Time and Structure: A Unified Synthesis of Atavistic Gene Expression and Topological Phase Transitions in Biological Aging
The scientific investigation of biological aging has traditionally been divided between molecular-genetic perspectives of informational degradation and systemic-physical models of topological network decline. This paper presents a unified theoretical synthesis bridging these epistemological domains by integrating the Atavistic Genetic Expression Dissociation (AGED) hypothesis with the physics of topological phase transitions in disordered media. We propose that the macroscopic structural entropy observed in the aging neural connectome is fundamentally driven by microscopic phylogenetic regression, wherein cells lose their morphostatic information and revert to ancient, unicellular transcriptional states.